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Ten percent of Americans are reported to suffer from a depressive disorder. This category of mental diseases includes major depression. The main symptoms of major depression are the following: Feeling numb emotionally, crying easily for "no reason", feeling slowed down or feeling unsatisfied and unable to sit still, putting on or losing weight, thoughts about suicide or death; trouble thinking, recalling things or focusing; trouble sleeping, in particular in the early morning or waiting to sleep all the time; feeling emotionally numb. Depression is thought to be related to chemical imbalances in the brain that makes it hard for cells to communicate with one another. Depression can result from nerve-racking situations, such as the death of someone you love, a divorce or redundancy. But it can also come unexpectedly. Certain medications, drugs and alcohol, or chronic diseases, such as diabetes or heart problems, can cause depression. Depression can be cured with medications, or specialist type of counseling called psychotherapy, or with both. Antidepressants are medications used to help people suffering from depression. Most people with depression feel better with treatment that includes these medications. Chemicals in the brain called neurotransmitters are required for regular brain function. Antidepressants help make the chemicals more available to the brain. Usually, antidepressants are taken at least for 6-12 months. They can better your mood, sleep, appetite and concentration. It may take several weeks for them to help. There are a few types of antidepressants. You and your medical practitioner may have to try several before discovering what medication is the most effective for you. Drugs sometimes lead to unwanted side effects. They may range from patient to patient and from medication to medication. For instance, when you first start your antidepressant you may feel exhausted, have trouble sleeping or feel sick to your stomach. These side effects ordinarily go away after a while. Nonetheless, even after a year of treatment, there is still about a 10% probability of depression returning as soon as treatment is over. Some people take antidepressants for several years.